COMPUTATIONAL MODELS

The aim of the U-Vir project is to develop a computational model (U-VIR) capable of assessing the susceptibility of SARS-Cov-2 and other viruses to the ultraviolet spectrum (UVC) and to validate the model with laboratory tests with UVC irradiating system developed by OMICA for the scope. As known, ultraviolet radiation has a germicidal power and lamps that emit at 254 nm are currently used to sterilize surfaces and environments. The computational model has been tuned to single stranded RNA/DNA viruses, double stranded RNS/DNA viruses and bacteria, showing good correlation with experimental data.

The computational model is based on the genomic content of RNA/DNA and on the photodimerization process that affects pyrimidines rather than purines. Other secondary factors like the hyperchromicity, the ultraviolet scattering due to the size of the organism and environmental conditions (temperature and relative humidity) are appropriately included in the modelling.

The model has been validated both using experimental data retrieved by about seventy scientific articles and performing a laboratory measurement of Sars-Cov-2 susceptibility.

The computational model has been included in a desktop application that allows the User to select an organism (i.e.: virus or bacteria), define environmental conditions (i.e. temperature and relative humidity) and automatically elaborate the request searching and downloading genomic information and returning, at the end of the processing, the Ultraviolet dose needed to obtain the 90% of virus reduction. It can downloaded below: 

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To run the application:

  1. Dowload the .zip file
  2. Unzip the file
  3. Run the UVir_v2 executable file

For further information send an email to uvir@uvsan.org

User can access and view the data accessing to the web-platform UVSAN https://uvsan.org

To get the authorization, please send a message to uvir@uvsan.org

The model has been customized for single stranded, double stranded viruses, bacteria and the results are summarized in the figures below

UVC Susceptibility for Double Stranded Viruses
UVC Susceptibility for Bacteria
UVC Susceptibility for Single Stranded Virus

The U-Vir project has been developed in the frame of the European Open Science Cloud Secretariat – Co-Creation activity contract n. 92.

EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant Agreement number 831644